Assessing the risk of osteonecrosis of the jaw due to bisphosphonate therapy in the secondary prevention of osteoporotic fractures

F. Lapi, F. Cipriani, A. P. Caputi, G. Corrao, A. Vaccheri, M. C. Sturkenboom, M. Di Bari, D. Gregori, F. Carle, T. Staniscia, A. Vestri, M. Brandi, V. Fusco, G. Campisi, G. Mazzaglia, on behalf of the Bisphosphonates Efficacy-Safety Trade- off (BEST) study group

May 23 2012

F. Lapi : F. Cipriani : G. Mazzaglia
Regional Agency for Healthcare Services of Tuscany, Florence, Italy

F. Lapi
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy

F. Lapi
Centre for Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, QC, Canada

A. P. Caputi
Department of Medicine and Pharmacology, University of Messina, Messina, Italy

G. Corrao
Unit of Biostatistics and Epidemiology, Department of Statistics, University of Milan-Bicocca, Milan, Italy

A. Vaccheri
Department of Pharmacology, University of Bologna, Bologna, Italy

M. C. Sturkenboom : G. Mazzaglia
Department of Medical Informatics, Pharmacoepidemiology Unit, Erasmus University Medical Center, Rotterdam, The Netherlands
the occurrence of ONJ appears rare among oral bisphosph- onates (BPs) users, it is important to know that it exists and can be opportunely minimized.

M. Di Bari
Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, Florence, Italy

D. Gregori
Department of Public Health and Environmental Medicine, University of Padua, Padua, Italy

F. Carle
Center of Epidemiology, Biostatistics, and Medical Information Technology, Polytechnic University of Marche, Ancona, Italy

T. Staniscia
Department of Medicine and Aging, University “G. d’Annunzio”, Chieti-Pescara, Italy

A. Vestri
Department of Public Health and Infectious Disease, University “La Sapienza”, Rome, Italy

M. Brandi
Department of Internal Medicine, University of Florence, Florence, Italy

V. Fusco
Oncology Unit, Alessandria Hospital, Alessandria, Italy


Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.

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